The Village of East Syracuse grew along side of the New York Central Railroad System, and accommodating the needs of the railroad workers and their families. At the time of incorporation the Village had 1,099 residents. Today the Village’s 1.6 square miles is home to 3,178. The Village of East Syracuse is located at the cross roads of NYS routes 690 and 481, just south of the NYS Thruway. The Village of East Syracuse is a “small town” with a friendly, cooperative atmosphere. The Village enjoys a thriving business community with major retail chains, manufacturing, and the pharmaceutical giant Bristol Myers-Squibb Company.